Cruise from California through the Panama Canal, one of the man-made wonders of the world. The canal is 100 years old but is still an awe inspiring engineering feat, and the best way to experience it is on a cruise.
Panama Canal cruises depart from Los Angeles, San Diego or San Francisco. They finish in Miami, Fort Lauderdale, Tampa or New York.
On your journey you'll visit tropical ports in countries like Mexico, Costa Rica and Colombia.
15-night Panama Canal cruise on Princess. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Huatulco (Mexico), San Juan del Sur (Nicargua), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Cartagena (Colombia).
• 2024 departure: January 7.
16-night Panama Canal cruise on Regent Seven Seas. One-way from Los Angeles to Miami (Florida). Visit Ensenada (Mexico), Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2024 departure: January 8.
15-night Panama Canal cruise on Norwegian. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Manzanillo (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Panama City (Panama) and Cartagena (Colombia).
• 2024 departure: January 12.
15-night Panama Canal cruise on Holland America. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, Cartagena (Colombia) and Half Moon Cay (Bahamas).
• 2024 departure: January 19.
15-night Panama Canal cruise on Princess. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Huatulco (Mexico), San Juan del Sur (Nicargua), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Cartagena (Colombia).
• 2024 departure: February 6.
15-night Panama Canal cruise on Holland America. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, Cartagena (Colombia) and Half Moon Cay (Bahamas).
• 2024 departure: April 6.
15-night Panama Canal cruise on Princess. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Huatulco (Mexico), San Juan del Sur (Nicargua), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Cartagena (Colombia).
• 2024 departure: May 9.
18-night Panama Canal cruise on Crystal. One-way from Los Angeles to New York City (New York). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Caldera (Costa Rica), the Panama Canal, Grand Cayman (Cayman Islands) and Miami (Florida).
• 2024 departure: August 27.
15-night Panama Canal cruise on Celebrity. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2024 departure: September 19.
16-night Panama Canal cruise on Princess. One-way from San Francisco to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Cartagena (Colombia).
• 2024 departure: September 28.
14-night Panama Canal cruise on Royal Caribbean. One-way from Los Angeles to New Orleans (Louisiana). Visit Cabo San Lucas (Mexico), Huatulco (Mexico), Puntarenas (Costa Rica), the Panama Canal and Cartagena (Colombia).
• 2024 departure: September 28.
15-night Panama Canal cruise on Carnival. One-way from San Francisco to Galveston (Texas). Visit Cabo San Lucas (Mexico), Puntarenas (Costa Rica), the Panama Canal and Cartagena (Colombia).
• 2024 departure: October 1.
16-night Panama Canal cruise on Holland America. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Puerto Caldera (Costa Rica), the Panama Canal, and Aruba.
• 2024 departure: October 4.
16-night Panama Canal cruise on Royal Caribbean. One-way from Los Angeles to Tampa (Florida). Visit Cabo San Lucas (Mexico), Mazatlan (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, Colon (Panama), Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2024 departure: October 5.
16-night Panama Canal cruise on Holland America. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Puerto Caldera (Costa Rica), the Panama Canal, and Aruba.
• 2024 departure: October 10.
17-night Panama Canal cruise on Norwegian. One-way from Los Angeles to Tampa (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Manzanillo (Mexico), Zihuatanejo (Mexico), Puerto Chiapas (Mexico), Acajutla (El Salvador), San Juan del Sur (Nicaragua), Puntarenas (Costa Rica), Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2024 departure: November 7.
16-night Panama Canal cruise on Princess. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), San Juan del Sur (Nicargua), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2024 departure: November 17.
15-night Panama Canal cruise on Norwegian. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Manzanillo (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Panama City (Panama) and Cartagena (Colombia).
• 2024 departure: December 6.
16-night Panama Canal cruise on Princess. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), San Juan del Sur (Nicargua), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2024 departure: December 19.
15-night Panama Canal cruise on Holland America. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puerto Caldera (Costa Rica), the Panama Canal, Cartagena (Colombia) and Half Moon Cay (Bahamas).
• 2025 departure: January 3.
16-night Panama Canal cruise on Norwegian. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Panama City (Panama), Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2025 departure: January 5.
16-night Panama Canal cruise on Regent Seven Seas. One-way from Los Angeles to Miami (Florida). Visit Ensenada (Mexico), Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Panama City (Panama), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2025 departure: January 8.
16-night Panama Canal cruise on Princess. One-way from San Francisco to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Cartagena (Colombia).
• 2025 departure: January 20.
16-night Panama Canal cruise on Oceania. One-way from Los Angeles to Miami (Florida). Visit Ensenada (Mexico), Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Cornito (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2025 departure: January 24.
15-night Panama Canal cruise on Norwegian. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Puerto Vallarta (Mexico), Manzanillo (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), Panama City (Panama) and Cartagena (Colombia).
• 2025 departure: February 6.
16-night Panama Canal cruise on Princess. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2025 departure: February 21.
16-night Panama Canal cruise on Princess. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2025 departure: March 25.
18-night Panama Canal cruise on Regent Seven Seas. One-way from San Francisco to Miami (Florida). Visit Los Angeles (California), Ensenada (Mexico), Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2025 departure: June 6.
20-night Panama Canal cruise on Oceania. One-way from San Diego to New York (New York). Visit Cabo San Lucas (Mexico), Ixtapa (Mexico), Puerto Quetzal (Guatemala), Corinto (Nicaragua), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia), George Town (Grand Cayman), Miami (Florida) and Port Canaveral (Florida).
• 2025 departure: July 3.
16-night Panama Canal cruise on Princess. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Manzanillo (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2025 departure: September 15.
16-night Panama Canal cruise on Celebrity. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia), Falmouth (Jamaica) and Grand Cayman (Cayman Islands).
• 2025 departure: September 19.
18-night Panama Canal cruise on Cunard. One-way from San Francisco to Miami (Florida). Visit Los Angeles (California), Cabo San Lucas (Mexico), Puntrenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Oranjestad (Aruba).
• 2025 departure: September 28.
16-night Panama Canal cruise on Princess. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2025 departure: September 30.
18-night Panama Canal cruise on Norwegian. One-way from San Francisco to Miami (Florida). Visit Los Angeles (California), Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), Panama City (Panama) and Cartagena (Colombia).
• 2025 departure: October 2.
16-night Panama Canal cruise on Royal Caribbean. One-way from San Diego to Fort Lauderdale (Florida). Visit Cabo San Lucas (Mexico), Mazatlan (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, Colon (Panama), Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2025 departure: October 4.
16-night Panama Canal cruise on Carnival. One-way from San Francisco to Galveston (Texas). Visit Cabo San Lucas (Mexico), Puntarenas (Costa Rica), the Panama Canal, Cartagena (Colombia) and Grand Cayman (Cayman Islands).
• 2025 departure: October 6.
17-night Panama Canal cruise on Holland America. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Acajutla (El Salvador), Puntarenas (Costa Rica), the Panama Canal and Aruba.
• 2025 departure: October 9.
14-night Panama Canal cruise on Norwegian. One-way from San Diego to Miami (Florida). Visit Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Panama City (Panama), Cartagena (Colombia) and George Town (Grand Cayman).
• 2025 departure: October 18.
16-night Panama Canal cruise on Princess. One-way from Los Angeles to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Aruba.
• 2025 departure: October 22.
17-night Panama Canal cruise on Holland America. One-way from San Diego to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Huatulco (Mexico), Puerto Chiapas (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), the Panama Canal, Oranjestad (Aruba) and Half Moon Cay (Bahamas).
• 2025 departure: November 1.
15-night Panama Canal cruise on Norwegian. One-way from Los Angeles to Miami (Florida). Visit Cabo San Lucas (Mexico), Acapulco (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), Panama City (Panama) and Cartagena (Colombia).
• 2025 departure: December 5.
16-night Panama Canal cruise on Princess. One-way from San Francisco to Fort Lauderdale (Florida). Visit Puerto Vallarta (Mexico), Puerto Quetzal (Guatemala), Puntarenas (Costa Rica), Fuerte Amador (Panama), the Panama Canal and Cartagena (Colombia).
• 2025 departure: December 7.
